Subcellular distribution of glycogen and decreased tetanic calcium in fatigued single intact mouse muscle fibres

摘要

Since the turn of the century the physiological and metabolic regulators of fatigue within skeletal muscle have been extensively researched (Hill, 1925). It is well established that calcium (Ca2+), released from the sarcoplasmic reticulum (SR), plays an integral role in skeletal muscle contractile function through the initiation of cross bridge cycling. It has been observed in vitro that SR Ca2+ release reduces during the onset of fatigue, which is believed to explain the subsequent loss of force generation within skeletal muscle. A series of recent ex vivo experiments have shown that the loss of Ca2+ release from the SR is paralleled with a reduced availability of endogenous skeletal muscle glycogen stores (0rtenblad et al 2013).