at least one chemical entity, composition, and methods for treating a patient having a condition, for enhancing skeletal muscle function or activity, for enhancing skeletal muscle efficiency, for increasing the time of rapid skeletal muscle fiber fatigue, for sensitize a fast skeletal muscle fiber to produce strength in response to low calcium ion concentrations and to increase skeletal muscle fatigue time

摘要

at least one chemical entity, composition, and methods for treating a patient having a condition, for enhancing skeletal muscle function or activity, for enhancing skeletal muscle efficiency, for increasing skeletal muscle fiber fatigue time, for Sensitizing a fast skeletal muscle fiber to produce strength in response to low calcium ion concentrations and to increase the time of skeletal muscle fatigue Certain chemical entities are provided, and methods of use for modulating skeletal myosin, skeletal actin, skeletal tropomyosin, troponin and skeletal muscle. , skeletal troponin i, skeletal t troponin, and skeletal muscle, including fragments and isoforms thereof, as well as skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle loss, lameness, weakness, metabolic syndrome, atrophy of muscle associated with desu so, and muscle fatigue, and other indications.