Carbonarones A and B,New Bioactive gamma-Pytone and alpha-Pyridone Derivatives from the Marine-derived Fungus Aspergillus carbonarius

摘要

Two new secondary metabolites,carbonarones A (1) and B (2),were obtained from the culture of the marine-derived fungus Aspergillus carbonarius isolated from the marine sediment collected at Weizhou island of China.Based on ESIMS,ID and 2D NMR data,and the X-ray crystallographic analysis,their structures were elucidated as 6-benzyl-4-oxo-4H-pyran-3-carboxamide and 6-benzyl-4-hydroxy-2-oxo-l,2-dihydropyridine-3-carbaldehyde,respectively.1 and 2 showed moderate cytotoxicity against K562 cells with IC50 values of 56.0 and 27.8 mug/ml,respectively.