Synthesis of 9-substituted tetrahydrodiazepinopurines - asmarine A analogues

摘要

Asmarines are marine alkaloids, with a unique tetrahydro[1,4]diazepino-[1,2,3-g,h]purine (THDAP) structure and interesting biological properties. Three synthetic approaches were employed for the preparation of the THDAP system. Several N-9, of the purine, protecting groups were investigated. N-15-Chemical shifts measured from (NH)-N-15 HMBC experiments for several compounds, that demonstrate the influence of various structural features on the N-15-resonances are reported. (C) 2003 Elsevier Ltd. All rights reserved. [References: 16]