An efficient large scale resolution of (+-)-threo-methylphenidate hydrochloride (Ritalin hydrochloride)

摘要

An efficient and large scale preparation of (2R,2'R)-(+)-threo-methylphenidate hydrochloride (3) by the resolution of (+-)-threo-methylphenidate hydrochloride (1) salt with O, O' -dibenzoyl-D-(+)-tartaric acid in the presence of 4-methylmorpholine is described.