Synthesis of polysaccharides having specific biological activities

摘要

Several types of stereoregular poly saccharides such as linear, branched, amino, and deoxy polysaccharides were synthesized by ring-opening polymerization of anhydro-sugar derivatives to reveal the relationship between structure and biological activities. Their stereoregular and naturally occurring polysaccharides were sulfonated. It was found that the sulfonated polysaccharides had potent anti-human immunodeficiency yirus (anti-HIV) activities, which increased with an increase of the proportion of amino sugar and branched units on the main chain, but with a decrease of deoxy sugar units and branches. Another biological activity of sulfonated poly- saccharides, blood anti-coagulant activity, was also examined. An overview will be presented of various synthetic and natural polysaccharides having biological activities.