Peptide Synthesis

摘要

Chemical synthesis of peptides and peptide analogs is carried out either in solution or on some type of macroscopic or molecular support structure. Solid phase peptide synthesis (SPPS) usually involves successive couplings of N-protected amino acid derivatives to the N-terminus of a growing peptide chain, which is anchored by its C-terminus to an insoluble polymer resin, t-butoxycarbonyl (Boc) and 9-fluorenylmethoxycarbonyl (Fmoc) are commonly used as Na protecting groups during chemical peptide synthesis.