Cascade Resulting in the Reductive Ethynylation of Aldehydes: Dissection of Its Components

摘要

A mild and efficient two-carbon homologation of aldehydes exploiting multiple modes of KOf-Bu was developed. This process involves a sequential Peterson allenylation/allene-alkyne isomerization/ protodesilylation in a single-flask operation. The differential roles played by the various elements of the process were demonstrated through dissection experiments.