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首页> 外文期刊>Diabetes >Impact of rs361072 in the Phosphoinositide 3-Kinase p110[beta] Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle
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Impact of rs361072 in the Phosphoinositide 3-Kinase p110[beta] Gene on Whole-Body Glucose Metabolism and Subunit Protein Expression in Skeletal Muscle

机译：磷酸肌醇3-激酶p110β基因中的rs361072对骨骼肌整体葡萄糖代谢和亚基蛋白表达的影响

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摘要

Phosphoinositide 3-kinase (PI3K) is a major effector in insulin signaling. rs361072, located in the promoter of the gene (PIK3CB) for the p110beta subunit, has previously been found to be associated with homeostasis model assessment for insulin resistance (HOMA-IR) in obese subjects. The aim was to investigate the influence of rs361072 on in vivo glucose metabolism, skeletal muscle PI3K subunit protein levels, and type 2 diabetes.
机译：磷酸肌醇3-激酶（PI3K）是胰岛素信号传导中的主要效应器。 rs361072位于p110beta亚基的基因（PIK3CB）的启动子中，先前已发现与肥胖受试者体内胰岛素抵抗（HOMA-IR）的稳态模型评估有关。目的是研究rs361072对体内葡萄糖代谢，骨骼肌PI3K亚基蛋白水平和2型糖尿病的影响。

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  • 来源
    《Diabetes》 |2010年第4期|p.1108-1112|共5页
  • 作者

    Rasmus Ribel-Madsen Pernille Poulsen Johan Holmkvist Brynjulf Mortensen Niels Grarup Martin Friedrichsen Torben Jørgensen Torsten Lauritzen Jørgen F P Wojtaszewski Oluf Pedersen Torben Hansen Allan Vaag;

  • 作者单位

    Rasmus Ribel-Madsen,1 Perniile Poulsen,1 Johan Holmkvist,2 Brynjulf Mortensen,1 Niels Grarup,2 Martin Friedrichsen,1,3 Torben Jørgensen,4*6 Torsten Lauritzen,6 Jörgen F.P. Wojtaszewski,7 Oluf Pedersen,2*3,8 Torben Hansen,2'9 and Allan Vaag1,10From the 'Steno Diabetes Center, Gentofte, Denmark, the 2Hagedorn Research Institute, Gentofte, Denmark, the department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, the 4Research Centre for Prevention and Health, Glostrup Hospital, Copenhagen, Denmark, die r,Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, the eDepartment of General Practice, Institute of Public Health, Aarhus University, Aarhus, Denmark, the department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark, the "Faculty of Health Sciences, University of Aarhus, Aarhus, Denmark, the 9FaCuUy of Health Sciences, University of Southern Denmark. Odense, Denmark, and the '"University Hospital MAS, Lund University, Malmo, Sweden.Corresponding author Rasmus Ribel-Madsen, rrma@steno.dk.Received 12 September 2009 and accepted 18 January 2010. Published ahead of print at http://diabetes.diabetesjoiurials.org on 27 January 2010. DOI: 10.2337/db09-1359.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/ucenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "adi-ertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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