Pharmacokinetics in Real Life: Sex and Gender Differences

摘要

Practitioners are often troubled by the lack of well characterized data on appropriate drug dosing, on effectiveness of treatment, and on drug safety for women and for women in pregnancy. We continue to struggle with how to best treat women during pregnancy and with the real life sex and gender differences in drug pharmacokinetics. This presentation looks at sex differences as a platform for considering the pharmacological status of women and how pregnancy changes that status. Specific examples of sex and gender differences in drug disposition/pharmacokinetics are discussed. The examples describe how sex-based differences influence treatment options and goals.