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Deregulated Expression of Superoxide Dismutase-2 Correlates with Different Stages of Cervical Neoplasia

机译:超氧化物歧化酶2的失调表达与宫颈癌的不同阶段相关。

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Objective: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer.Methods: In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO).Results: We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining.Conclusions: Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease.
机译:目的:超氧化物歧化酶2(SOD2)被认为是调节正常和致瘤细胞中细胞氧化还原状态的最重要的抗氧化酶之一。该酶的过表达可能与癌变有关,特别是在肺癌,胃癌,结直肠癌和乳腺癌中。方法:在本研究中,我们通过免疫组织化学(IHC)评价了331例宫颈组织学样本(包括31例低级别宫颈癌)中的SOD2蛋白水平。上皮内瘤样病变(LSIL),51例高级别宫颈上皮内瘤样病变(HSIL),197例鳞状上皮癌(SCC)和52例宫颈腺癌(ADENO)。结果:我们观察到SOD2染色随宫颈疾病严重程度而增加。在13%的LSIL,25.5%的HSIL和40%的SCC中发现了强烈的SOD2染色。此外,65.4%的ADENO表现出强烈的SOD2染色。结论:SOD2表达的差异可能被用作表征宫颈疾病不同阶段的生物标志物。

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