EBV、ERK1、Ki67在不同临床分型宫颈癌中的表达及其相关性

摘要

目的 研究EBV、ERKl和Ki67在同临床分型宫颈癌中的表达及相互关系,以探讨宫颈癌的发病机制及其临床意义.方法 选择经手术治疗、有明确病理诊断的宫颈癌患者共109例,其中Ⅰ期31例,Ⅱ期14例,Ⅲ期37例和Ⅳ期27例,使用免疫组织化学染色法检测EBV的表达、ERKl和Ki67的表达.同时选取30例正常宫颈石蜡切片作为对照组.结果 EBV、ERKl和Ki67表达随着宫颈癌临床分型而逐渐增加,与0期和Ⅰ期相比,差异均有统计学意义,P<0.05.结论 EBV感染可能是宫颈癌发生原因之一,ERKl的表达以及Ki67可作为评价宫颈癌的发生、发展中的重要指标.%Objective To search the relationship between the expression of EBV,ERK 1 and Ki67 and different clinical classification of cervical cancer and try to explore the pathogencsis of cervical cancer and its clinical significance. Methods A total of 109 cases of clear pathological diagnosis of cervical cancer patients,including stage I (31 cases) , H (14 cases), [1(37 cases) and R1' (27 cases) . Immunohistochcmical staining was used to detect EBV,ERK 1 and Ki67 expression. And 30 paraffin sections of normal cervix people served as controls. Results The expression of EBV,ERK 1 and Ki67 gradually increased as cervical cancer clinical classification. The differences were statistically significant(P< 0. 05) compared with stage 0 and I . Conclusion EBV infection may be one of the causes of cervical cancer and ERK 1 and Ki67 expression may play an important indicator evaluation of occuring and development of cervical cancer.