首页> 外文会议>2011 International Conference on Human Health and Biomedical Engineering >Clinical role of hWAPL in histologic diagnosis of cervical cancer and cervical intraepithelial neoplasia: Correlation with p16INK4a expression and HPV testing
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Clinical role of hWAPL in histologic diagnosis of cervical cancer and cervical intraepithelial neoplasia: Correlation with p16INK4a expression and HPV testing

机译:hWAPL在宫颈癌和宫颈上皮内瘤变的组织学诊断中的临床作用:与p16INK4a表达和HPV检测的相关性

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In this study, we examined the expression of hWAPL in cervical intraepithelial neoplasia (CIN) I-III and cervical squamous cell carcinoma, and investigated clinical application value of hWAPL in diagnosis of cervical disease. 90 samples were collected, and two slides from each sample were immunostained using hWAPL and p16INK4a antibody. HPV-DNA testing was performed using the HC2 DNA test. The expression intensity of hWAPL in SCC group, CIN III group, CIN II group and CIN I group was obviously higher than that in normal cervix group, and the expression intensity in SCC group, CIN III group and CIN II group was higher than that in CIN I group. Based on ROC curves of hWAPL, when using ≥CIN I, ≥CIN II and ≥CIN III as cutoff for positive classification, area under the curve (AUC) was 0.815, 0.699, and 0.616, respectively. Therefore, hWAPL may be a promising candidate for diagnosis of low-grade CIN.
机译:在这项研究中,我们检查了hWAPL在宫颈上皮内瘤变(CIN)I-III和宫颈鳞状细胞癌中的表达,并探讨了hWAPL在宫颈疾病诊断中的临床应用价值。收集了90个样品,并使用hWAPL和p16INK4a抗体对每个样品的两个载玻片进行了免疫染色。 HPV-DNA测试是使用HC2 DNA测试进行的。 SCC组,CIN III组,CIN II组和CIN I组hWAPL的表达强度明显高于正常宫颈组,而SCC组,CIN III组和CIN II组的hWAPL表达强度均高于正常宫颈组。 CIN我分组。根据hWAPL的ROC曲线,当使用≥CINI,≥CINII和≥CINIII作为阳性分类的临界值时,曲线下面积(AUC)分别为0.815、0.699和0.616。因此,hWAPL可能是诊断低度CIN的有希望的候选者。

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