Relationship between serum γ?glutamyltransferase levels and acute exacerbation of chronic obstructive pulmonary disease

摘要

INTRODUCTION γ?glutamyltransferase (GGT) is a plasma membrane enzyme, which is involved in antioxidant glutathione resynthesis.OBJECTIVES The aim of the study was to compare the serum levels of GGT (which is considered a novel marker of oxidative stress) between patients with stable chronic obstructive pulmonary disease (COPD) and those with acute exacerbation of COPD, and the relationship of GGT with inflammation. PATIENTS AND METHODS The study involved 132 patients with exacerbated COPD and normal function of the liver and biliary tract (mean age, 66.6 ±10.1 years; men, 88.6%) and 147 patients with stable COPD (mean age, 65.4 ±8.8 years; men, 87.1%). Serum GGT and C?reactive protein (CRP) levels were measured and compared between the groups. RESULTS Serum GGT levels in patients with exacerbated COPD were significantly higher than in those with stable COPD (30 U/l; interquartile range [IQR], 18.8 vs. 25 U/l; IQR, 16; P