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Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease

机译:全基因组测序在A组侵袭性链球菌疾病暴发中的应用

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摘要

Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
机译:全基因组分析用于调查2种侵入性A组链球菌(GAS)感染的非典型点源传播。分离株为血清型M4,ST39,在遗传上无法区分。与MGAS10750的比较显示ropB中存在非同义多态性,并增加了speB转录。这项研究证明了全基因组分析对GAS爆发的有用性。

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