ZIC1 and GHSR, MOLECULAR DIAGNOSTIC MARKERS OF INVASIVE GLOBAL DISORDERS induced by HPV-induced, HOSPITAL DISEASES, AND ANOGENITITAL AREA, NON-INDUCED APPLICATIONS, NON-INDUCED APPLICATIONS

摘要

The present invention relates to a method for detecting high-grade precancerous lesions induced by HPV, invasive HPV-induced cancers and cancers of the female genital organs and the anogenital region not induced by HPV, this method comprising detecting the hypermethylation of the ZIC1 gene and / or GHSR in the cell, however, such hypermethylation indicates the presence of precursor lesions with invasive potential induced by HPV, invasive cancer diseases induced by HPV, and ie cancers of female genitals and genital area is not induced by HPV. The present invention also includes the use of the ZIC1 gene and / or GHSR in such a method and an assay kit for detecting the methylation of ZIC1 and / or GHSR.