：Objective To compare the clinical efficacy between silver sulfadiazine cream and magnesium sulfate solution in treatment of side effects caused by iodinated contrast media extravasation. Methods 〓Totally 88 patients with iodinated contrast media extravasation during CT contrast-enhanced scan were divided into two groups according to the treatment received. Patients in the observation group(n=44)were given external application of silver sulfadiazine cream, and those in the control group(n=44)received wet compression of magnesium sulfate 50% solution. The treatment efficacy in relieving pain and swelling was evaluated at 48 hours after interventions. Results 〓In terms of low-grade extravasation of the contrast media, there were no significant difference in cure rate between two groups(100.00% vs. 92.00%, P0.05 ). In terms of medium-grade extravasation of the contrast media, the cure rate in the observation group was higher than that in the control group(89.47% vs. 68.42%, P0.05). Only 4 patients developed skin blister in the control group. Conclusion 〓Compared with wet compression of magnesium sulfate 50% solution, the external application of silver sulfadiazine cream is more effective to relieve the pain and swelling in patients with medium-grade extravasation of iodinated contrast media.
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