Personality lifestyle and job satisfaction: causal association between neuroticism and job satisfaction using Mendelian randomisation in the UK biobank cohort

摘要

Directed acyclic graph demonstrating ( ) Standard Mendelian randomization approach and ( ) Multivariable Mendelian randomization approach using two exposures and two instruments. In the present study, genetic risk score derived from genetic variants associated with their respective exposures (neuroticism, education and physical activity) were used as instruments to assess the causal association between exposures and outcome (job satisfaction).