Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics

摘要

IntroductionThe tumor suppressor gene HIC1 (Hypermethylated in Cancer 1) which encodes a transcriptional repressor with multiple partners and multiple targets is epigenetically silenced but not mutated in tumors. HIC1 has broad biological roles during normal development and is implicated in many canonical processes of cancer such as control of cell growth, cell survival upon genotoxic stress, cell migration and motility.