IL-3/GM-CSF receptor promotes stem cell expansion monocytosis andatheroma macrophage burden in mice with hematopoietic Apoedeficiency

摘要

ObjectiveCoronary heart disease is associated with monocytosis. Studies using animal models of monocytosis and atherosclerosis such as Apoe^-/- mice have shown bone marrow (BM) hematopoietic stem and multi-potential progenitor cell (HSPC) expansion, associated with increased cell surface expression of the common β subunit of the GM-CSF/IL-3 receptor (CBS) on HSPCs. Apoe^-/- mice also display increased GM-CSF-dependent monocyte production in the spleen. We investigated the role of the CBS in cholesterol-driven HSPC expansion, monocytosis and atherosclerosis.