高位结肠透析联合中药保留灌肠对慢性肾衰患者肾功能的影响

摘要

Objective:To observe the effect of high colon dialysis combined with Chinese medicine retentive enema treatment for chronic renal failure ( CRF) .Methods:Thirty-two patients received conventional treatment ( Group A) and 31 patients were given conventional treatment combined with Chinese medicine retentive enema ( Group B) and 34 cases were treated by conventional treatment plus high colon dialysis combined with traditional Chinese medicine retentive enema (Group C).The change of urea ni-trogen (Bun), serum creatinine (Scr), serum uric acid (UA), endogenous creatinine clearance urinary inhibition (Ccr), Cysta-tin C ( CysC) and parathyroid hormone ( PTH) were observed before and after in each group .Results:Group C showed significant difference after treatment in reducing Bun , Scr, UA, CysC, PTH and rising Ccr (P<0.01).Group B also showed the difference before and after the treatment (P<0.05), while the effect of Group C was better than that of the Group B (P<0.05).The im-provement in Group A was not good after treatment (P>0.05).Conclusion:High colon dialysis combined with Chinese medicine retain enema may significantly improve renal function , reduce the PTH , delay the progress of CRF , and is superior to the combina-tion of traditional Chinese medicine enema and conventional treatment .%目的：观察高位结肠透析联合中药保留灌肠治疗慢性肾衰（Chronic Renal Failure，CRF）的疗效。方法：使用常规治疗32例患者（A组），与常规治疗＋中药保留灌肠31例患者（B组），以及常规治疗＋高位结肠透析联合中药保留灌肠治疗34例患者（C组）进行随机对照，观察每组治疗前后尿素氮（Urea Nitrogen，Bun）、血清肌酐（Serum Creatinine，Scr）、血清尿酸（Uric Acid，UA）、内生肌酐清除率（Creatinine Clearance Rate，Ccr）、胱抑素C（Cystatin C，CysC）、甲状旁腺激素（Para-thyroid Hormone ，PTH）变化情况，比较3组疗效。结果：C组治疗后在降低Bun、Scr、UA、CysC、PTH，升高Ccr方面与治疗前有着统计学意义（P＜0.01），B组治疗前后同样具有统计学意义（P＜0.05），同时C组较B组占优（P＜0.05）；而A组治疗前后改善不理想（P＞0.05）。结论：提示高位结肠透析联合中药保留灌肠能明显改善肾功能，降低PTH，延缓CRF的进展，且优于传统中药灌肠以及常规治疗。