MicroRNA(miRNA)是约为22个核苷酸的RNA分子,参与基因表达的转录后调节,调节细胞的生长、分化、细胞周期、凋亡,与肿瘤的发生、发展密切相关.近年来研究表明,血清、脱落细胞等来源的游离miRNA也具有特异性与稳定性,有可能作为宫颈癌及其他肿瘤早期诊断的分子标志物.现就miRNA与宫颈癌前病变、宫颈癌的关系及miRNA在宫颈癌诊断治疗中的临床应用前景予以综述.%MicroRNA( miRNA )has approximately 22 nucleotides that ran mediate the post-transcrip-tional regulation of gene expression. miRNA regulates" cellular processes such as development, differentiation, reil cycling, apoptosis and are closely associated with tumors. In recent years, studies have shown that dissociation miRNA from cast-off cells or serum has its own specificity and stability, and can serve as a bi-omarker for the early diagnosis of cervical cancer and other tumors. Here is to make a review on the relationship between miRNA and cervical cancel- and its clinical application in the diagnosis and treatment of cervical cancer.
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