坦度螺酮固定剂量治疗社交焦虑症的临床评价

摘要

Objective:To evaluate efficacy and safety of tandospirone in treatment of social anxiety disorder. Methods:66 so-cial anxiety disorder patients were divided into tandospirone and paroxetine for a random double-blind study. The efficacy and side effects were evaluated with Liebowitzs Social Anxiety Scale ( LSAS) , treatment emergent symptom scale ( TESS) , and clinical global impression scale ( CGI);and then renal function, liver function, electrocardiogram ( ECG) , electroencephalogram ( EEG) , biochemi-cal analysis ( Glu, K, Na, Cl) and the like were tested. Results:The clinical efficacy had no significant difference between tandospi-rone and paroxetine. The effective rates of two groups were separately 78. 1% and 79. 4% (P>0. 05). The side effects of tandospirone were less than those of paroxetine (P<0. 01). Conclusions: Tandospirone is an effective and highly safe drug in the treatment social anxiety disorder.%目的：：评价坦度螺酮治疗社交焦虑症的疗效和安全性。方法：用坦度螺酮和帕罗西汀进行随机双盲对照观察66例患者。采用Liebowitz社交焦虑量表( LSAS)、副反应量表( TESS)、临床总体印象量表( CGI)评价患者疗效和不良反应,并定期检查患者肝、肾功能、心电图、脑电图、血生化(Glu、K、Na、Cl)等。结果：坦度螺酮对社交焦虑症疗效与帕罗西汀相当,两组患者疗效分别为78.1%,79.4%,(P>0.05)。坦度螺酮的不良反应明显少于帕罗西汀(P<0.01)。结论：坦度螺酮是一种疗效较好、安全性较高的治疗社交焦虑症的药物。