埃索美拉唑、奥美拉唑与泮托拉唑治疗消化道溃疡的成本-效果分析

摘要

目的：评价埃索美拉唑、奥美拉唑与泮托拉唑3种三联方案治疗消化道溃疡的成本-效果。方法：选取本院2013年1-7月收治的114例消化性溃疡患者，按照随机数字表法将其分为A、B、C组各38例，A组给予埃索美拉唑肠溶片+克拉霉素片+阿莫西林片，B组给予奥美拉唑肠溶片+克拉霉素片+阿莫西林片，C组给予泮托拉唑肠溶胶囊+克拉霉素片+阿莫西林片，运用药物经济学成本-效果分析法对3种方案进行分析。结果：3组的治疗效果中，A组总有效率94.7%最高，其次为C组89.5%，B组86.8%最低，但组间比较差异均无统计学意义（P>0.05）；3组成本-效果比分别为9.83、3.97、5.42。结论：3种治疗方案中，奥美拉唑联合两种抗菌药物治疗消化道溃疡的方案较优，且安全性较高，值得在临床上推广。%Objective:To evaluate the cost-effectiveness of esomeprazole,omeprazole and pantoprazole three therapeutic regimens in the treatment of peptic uler.Method:A total of 114 patients with peptic ulcer were selected in our hospital from January 2013 to July 2013,they were randomly divided into group A,group B and group C,38 cases in each group.The group A was treated with esomeprazole+clarithromycin+amoxicillin,the group B was treated with omeprazole+amoxicillin+clarithromycin,the group C was treated with pantoprazole+clarithromycin+amoxicillin.Three therapeutic schemes were analyzed by using pharmacoeconomic cost-effectiveness analysis.Result:The treatment effect of the 3 groups, the total efficiency of group A was 94.7%,it was the highest,followed by group C was 89.5%,group B was 86.8%,it was the lowest,but there was no significant difference in the three groups(P>0.05),ratio of cost-effectiveness was 9.83,3.97, 5.42.Conclusion:In 3 types of treatment,omeprazole combined with two kinds of antibacterial drugs in the treatment of peptic ulcer is better,and the safety is high,it is worth promoting in clinical practice.