不同程度肺炎患儿分泌型白细胞蛋白酶抑制剂与核因子-κB 水平变化及临床意义

摘要

Objective To investigate the changes and clinical significance of plasma secretory leukocyte pro‐teinase inhibitor(SLPI) and nuclear factor‐κB(NF‐κB) levels in children patients with different degrees of pneumoni‐a .Methods 66 children patients with bronchopneumonia in our hospital were selected and divided into the severe pneumonia group(30 cases) and the ordinary pneumonia group(36 cases) .The levels of serum SLPI and NF‐κB were detected within 24 h after admission ,on 5 d after treatment .Meanwhile 20 healthy children were selected as the healthy control group .Results Serum SLPI level before treatment in the severe pneumonia group and the ordinary pneumonia group was significantly lower than that in the healthy control group ,while the NF‐κB level was signifi‐cantly higher than that in the healthy control group(P < 0 .05) .The serum SLPI level after treatment in the severe pneumonia group and the ordinary pneumonia group were significantly increased compared with before treatment , while the NF‐κB level was significantly decreased(P < 0 .05) ,but serum SLPI level in the severe pneumonia group was still lower than that in the healthy control group ,while the NF‐κB level was still higher than that in the healthy control group ,the differences were statistically significant(P < 0 .05) ,the SLPI and NF‐κB levels had no statistical differences between the ordinary pneumonia group and the healthy control group(P> 0 .05) .Conclusion Early detec‐tion of serum SLPI and NF‐κB levels in children patiens with pneumonia conduces to early diagnosis ,treatment and prognosis of severe pneumonia .%目的：探讨不同程度肺炎患儿分泌型白细胞蛋白酶抑制剂（SLPI）与核因子‐κB（NF‐κB）水平变化及其临床意义。方法选择66例支气管肺炎患儿，分为普通肺炎组和重症肺炎组，分别在入院24 h 内（治疗前）和治疗5 d 后（治疗后）检测 SLPI 水平和 NF‐κB 表达水平，同时选择20例健康儿童作为健康对照组。结果治疗前，重症肺炎组和普通肺炎组患儿 SLPI 水平明显低于健康对照组，NF‐κB 水平明显高于健康对照组（P ＜0．05）。治疗后，重症肺炎组和普通肺炎组 SLPI 水平较治疗前显著升高，NF‐κB 水平显著降低（P ＜0．05），但重症肺炎组的 SL‐PI 水平仍低于健康对照组，NF‐κB 水平仍高于健康对照组，差异均有统计学意义（P＜0．05），普通肺炎组的 SLPI 水平和 NF‐κB 水平与健康对照组差异无统计学意义（P＜0．05）。结论对肺炎患儿早期检测 SLPI 及 NF‐κB 水平，有助于重症肺炎的早期诊断、治疗和预后。