不同肥胖指标与中老年男性血清睾酮水平的相关性研究

摘要

Objective To examine the relationship between waist circumference (WC),waist-hip ratio (WHR),body mass index (BMI),lipid accumulation product (LAP) and visceral adiposity index (VAI) and serum testosterone levels in middle-aged and elderly men.Methods A total of 1 003 men aged 40-75 years were recruited in this study.The anthropometric data were collected.The serum levels of testosterone and glycolipid metabolism-related parameters were quantitatively measured.The relationship between different indicators of obesity and serum levels of testosterone was analyzed.Results In the low testosterone level group (≤ 11.5 nmol/L),WC,WHR,BMI,LAP and VAI were significantly larger compared with those in the high testosterone level group (＞ 11.5 nmol/L),all P ＜ 0.001.The serum levels of testosterone were negatively correlated with WC,WHR,BMI,LAP and VAI (all P ＜ 0.001).After the adjustment of confounding factors of blood pressure,blood glucose and lipid,WC,WHR,BMI and LAP were still significantly correlated with testosterone level (all P ＜ 0.001).The correlation between WC and testosterone level was the highest (r=-0.360),followed by BMI (r =-0.343) and LAP (r =-0.261).Conclusions In middle-aged and elderly men,WC,WHR,BMI and LAP are negatively correlated with testosterone level.Among them,WC is the optimal indicator.%目的 了解中老年男性人群中腰围、腰臀比、BMI、脂质蓄积指数(LAP)、内脏脂肪指数(VAI)与血清睾酮水平的关系.方法 选取40 ～ 75岁男性1 003例为研究对象,收集其人体学测量数据,检测其血清总睾酮、糖脂代谢指标,分析肥胖各指标和血清睾酮的关系.结果 睾酮低下组(总睾酮≤11.5 nmol/L)的腰围、腰臀比、BMI、LAP、VAI大于睾酮正常组(总睾酮＞11.5 nmol/L),P均＜0.001;相关性分析提示腰围、腰臀比、BMI、LAP、VAI与总睾酮呈负相关(P均＜0.001),校正血压、血糖、血脂等混杂因素后,腰围、腰臀比、BMI、LAP与总睾酮的相关性仍有统计学意义(P均＜0.01),其中腰围与总睾酮水平的相关性最明显(r=-0.360),其次为BMI(r=-0.343)和LAP(r=-0.261).结论 中老年男性人群中,腰围、腰臀比、BMI、LAP与血清睾酮呈负相关,腰围是其中的较优指标.