Relationship Between Serum Testosterone,Leptin,Interleukin-6(il-6)Level and Insulin Sensitivity in Non-obese and Obese Male Subjects in Magway Region,Myanmar

摘要

Objective:To determine the relationship between insulin resistance and related variables(serum testosterone,interleukin(IL-6)and leptin level)in obese and non-obese healthy subjects.Methods:Community-based crosssectional,analytic study was undertaken in 60 subjects for each obese group(BMI≥30.0 kg/m2)and non-obese group(BMI 18.5 to 24.9 kg/m2)(age;18-45 years)residing in Magway Township from December 2016 to December 2017.Serum insulin,testosterone,IL-6 and leptin levels were measured by enzyme linked immunoassay,and serum fasting glucose was measured by glucose oxidase method.Insulin sensitivity was calculated by HOMA formula(Homeostatic Model Assessment).Results:HOMA-IR,serum leptin and IL-6 level were significantly higher in obese group while serum testosterone level was significantly lower in obese group.There was a significantly correlation between HOMA-IR with leptin(r=0.306,p=0.001),IL-6(r=0.237,p=0.009)and testosterone(r=-0.209,p=0.02).Moreover,serum leptin was significantly and positively correlated with IL-6(r=0.391,p<0.001)while serum testosterone was significantly and negatively correlated with leptin(r=-0.408,p<0.001),and IL-6(r=-0.34,p<0.001).Conclusions:Obese men are more likely to have low testosterone,high inflammatory markers leptin and Il-6,which were associated with decreased insulin sensitivity.