富于细胞性血管纤维瘤临床病理特点

摘要

目的：探讨富于细胞性血管纤维瘤（cellular angiofibroma，CAF）临床、病理特点、诊治方法及预后。方法：回顾性分析2000年1月至2014年12月国内报道收治的9例及我院新收治的1例的临床资料，对其临床、病理特点、诊断治疗方法及预后进行分析。结果：10例 CAF 患者均经手术病理确认，发病年龄27~65岁（平均45.1岁），其中男性3例，女性7例。临床表现：8例 CAF 患者多无明显症状，主诉多为发现包块逐渐增大（外阴4例、阴囊2例、腹股沟1例），其次为体检发现包块（1例）。病理切片特点为疏松排列的梭形细胞、脂肪瘤样细胞和突出的厚壁血管。免疫组织化学：肿瘤细胞 Viamentin 阳性，CD34阳性。CD31，SMA，S -100，HMB -45均阴性。10例均行手术治疗，随访8例，未见复发。结论：富于细胞性血管纤维瘤是一种罕见的良性的间叶性肿瘤，不易与具有血管纤维瘤样结构的软组织肿瘤鉴别，治疗上以手术为主，术后需严密复查。%Objective:To investigate the clinical,pathological features,diagnosis,treatment methods and prognosis of cellular angiofibroma(CAF). Methods:Retrospectively analyzed the clinical files of 9 CAF cases reported in Chi-na from 2000 - 2014,and a new CAF case in Shengjing Hospital of China Medical University,the clinical and patho-logical features,diagnosis and treatment mothods and prognosis were reviewed. Results:All 10 cases of CAF patients were confirmed by operation pathology. Of the 10 cases,the mean age was 45. 1 years(range:27 ~ 65 years old),7 fe-males and 3 males. Most of the cases showed gradually enlarged mass(vulva 4 cases,scrotum 2 cases,groin 1 case) and no other obvious symptoms was complained,1 case found mass just after body examination. The pathological sec-tions of cellular angiofibroma patients after operation was showed. The immunohistochemical results of the tumor cells showed positive of Viamentin and CD34. But CD31,SMA,S - 100,HMB - 45 were all negative. All these 10 cases re-ceived operation,8 cases were followed up,and no one reoccurred. Conclusion:Cellular angiofibroma is a rare benign mesenchymal tumor which should be distinguished from other soft tissues of angiofibroma. The main treatment method is surgical operation,and a strict follow up is needed.