硝酸镧对大鼠胃粘膜长期作用的实验研究

摘要

目的：探讨硝酸镧〔La(NO3)3〕长期口服对大鼠胃粘膜的影响。方法：应用常规组织学和形态计量学方法研究长期经口给予Wistar大鼠不同剂量的硝酸镧后 胃粘膜的变化。结果：给予硝酸镧6个月后，20和10 mg·kg-1组大鼠胃底腺上有较多胞质疏松 的壁 细胞；胃底腺壁细胞、主细胞、颈粘液细胞比值的变化与剂量呈一定相关性；20和10 mg·k g-1组雄性大鼠胃底腺颈粘液细胞内酸性粘液 物质的含量减少，2、0.2和0.1 mg·kg-1组雄性和雌性大鼠胃底腺颈粘液细胞 内酸性粘液物质的含量增加。结论：较高剂量(20和10 mg·kg-1)的硝酸镧长期口服引起胃粘膜的 损伤；较低剂量(2、0.2和0.1 mg·kg-1)的硝酸镧对胃粘膜有一定的保护作用。%Objective:To probe into the long-term effect of La(NO3)3 fed orally on gast ric mucosa of rats.Methods:The gastric mucosa of rats was studied after La(NO3)3 was administe red orally for a long-term,by the use of ordinary histological technology and m orphometry.Results:In the groups of 20 mg·kg-1 and 10 mg·kg-1,the cytopl asma of more parietal cells lying in the top of the gastric gland was loose.Proporti on of cell types of the gastric gland was related to the doses. The acid mucus l evel of the mucous neck cells of male rats in the groups of 20 mg·kg-1 an d 10 m·kg-1 decreased. In the groups of 2 mg2kg-1, 0.2 mg·kg -1 and 0.1 mg*kg-1,the acid mucus level of the mucous neck cells of both male and female rats increased.Conclusion:La(NO3)3 fed orally for a long-term could injure gastric muc osa in higher dose (20 mg·kg-1,10 mg·kg-1) but promote the protect ive action of the gastric mucosa in lower dose (0.2 mg·kg-1,0.1 mg·kg- 1).