A high performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS)method was developed for the determination of the migration of 27 perfluorinated compounds in food contact materials using 3％ acetic acid,10％ alcohol,50％ alcohol and olive oil as food simulants.Samples were soaked in 1 L different kinds of food simulants every 6 dm2 food contact materials according to (EU) No.10/2011.The water-based simulant samples could be analyzed directly after filteration,and the olive oil stimulant samples should be extracted with acetonitrile before analysis.Thesimulated solution samples were separated on a C18 column with methanol-water as mobile phase,and analyzed under multiple reaction monitoring(MRM) mode.The results showed that there existed good linearities(r ＞0.999 1) for 27 perfluorinated compounds in the range of 1-1 000 μg/L.The LOQs of PCFs were in the range of 0.28-9.85 μg/kg in food simulants.The recoveries for 27 perfluorinated compounds in blank samples at two spiked levels of 10 and 100 ng ranged from 82.6％ to 112.1％ with relative standard deviations(RSDs) of 2.2％-7.5％.%建立了食品接触材料迁移模拟环境中27种全氟化合物的高效液相色谱-串联质谱检测方法.选取乙酸(3％)、乙醇(10％、50％)和橄榄油作为食品模拟物,模拟了食品接触材料在与不同类型食物接触下的迁移行为,根据(EU)No.10/2011的要求对样品进行处理,每6 dm2食品接触材料加入1L食品模拟物浸泡.水相模拟物经过滤后直接检测,橄榄油经乙腈提取后进行检测.模拟溶液样品以甲醇-水混合溶液为流动相,经C18色谱柱分离,在MRM模式下进行检测.结果表明:全氟化合物在1～1 000 μg/L质量浓度范围内线性关系良好(r ＞0.999 1);全氟化合物在食物模拟物中的定量下限为0.28 ～9.85μg/kg;对空白样品进行10、100 ng两个浓度水平的加标回收试验,加标回收率为82.6％～ 112.1％,相对标准偏差为2.2％～7.2％.
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