介孔生物玻璃/磷酸钙骨水泥多级孔复合支架的制备及其载药特性研究

摘要

Hierarchically composite scaffold (MBG/CPC) was successfully prepared by loading of mesoporous bio-active glasses (MBG) into macroporous calcium phosphate cement (CPC) with simply centrifuging method. It is revealed that MBG loading capacity on CPC and the BET surface area of MBG/CPC can reach 47.2% and 100.1 m2/g, respectively. In contrast, almost no MBG loading is detected by using traditional impregnation route. Drug loading and releasing tests show that DOX loading capacity on hierarchically composite scaffold MBG/CPC is 46 mg/g, which is 11.5 times of that on pure CPC. Importantly, a sustained drug release in vitro performance is presented on MBG/CPC.%采用离心法将介孔生物活性玻璃(MBG)和磷酸钙骨水泥(CPC)高效复合制备出介孔/大孔多级孔复合支架材料,评价了其对抗癌药物阿霉素的装载及释放性能.实验结果表明,采用离心法能在大孔支架CPC内有效负载大量的介孔生物活性玻璃,使其比表面积高达100.1 m2/g,负载量达47.2％,而采用传统浸渍法则不能将MBG粉体材料负载于CPC支架上.载药实验发现离心法制备的介孔/大孔复合支架对阿霉素的装载量达到了46 mg/g,是普通大孔CPC支架的11.5倍,且在体外具有药物缓释的特性.