Objective:To explore the effects of nutritional support and intervention on intestinal flora,Th cellular im-mune response and inflammatory response in patients with severe ulcerative colitis. Methods:90 UC patients who were diag-nosed and treated in the hospital between August 2014 and January 2017 were divided into the control group(n=45)and the nutritional intervention group(n=45)by random number table. Control group received clinical routine therapy for UC,and nutritional intervention group received routine therapy as well as nutritional support and intervention. The differences in the in-testinal flora distribution,Th1/Th2 cytokine contents and inflammatory mediator contents were compared between the two groups. Results:Before intervention,there was no statistically significant difference in the intestinal flora distribution,Th1/Th2 cytokine contents and inflammatory mediator contents between the two groups. After intervention,the number of enter-obacter and enterococcus in nutritional intervention group were lower than those in control group whereas the number of lacto-bacilli,Bifidobacterium and clostridium butyricum were higher than those in control group;serum IL-2 and IFN-γ contents were lower than those of control group whereas IL-4 and IL-10 contents were higher than those of control group;serum MCP-1,MIP-1a and HMGB-1 contents were lower than those of control group. Conclusion:Nutritional support and intervention can further balance the intestinal flora distribution and Th1/Th2 immune response and suppress the systemic inflammatory response in patients with severe ulcerative colitis.%目的:探讨营养支持及干预对重度溃疡性结肠炎患者肠道菌群、Th细胞免疫应答、炎症反应的影响.方法:选择2014年8月~2017年1月间在本院确诊并接受治疗的UC患者90例,经随机数表法分为对照组、营养干预组各45例.对照组患者接受UC临床常规治疗,营养干预组患者在常规治疗同时加入营养支持及干预.对比两组肠道菌群分布、T h1/T h2细胞因子含量、炎症介质含量的差异.结果:干预前,两组肠道菌群分布、T h1/T h2细胞因子含量、炎症介质含量的差异无统计学意义.干预后,营养干预组中肠杆菌、肠球菌的数量低于对照组,乳酸杆菌、双歧杆菌、丁酸梭菌的数量高于对照组;血清中IL-2、IFN-γ的含量低于对照组,IL-4、IL-10的含量高于对照组;血清中MCP-1、MIP-1a、HMGB-1的含量低于对照组.结论:重度溃疡性结肠炎患者接受营养支持及干预,可进一步均衡肠道菌群分布及T h1/T h2免疫应答,抑制全身炎症反应.
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