Effects of nutritional support and intervention on intestinal flora, Th cellular immune response and inflammatory response in patients with severe ulcerative colitis

摘要

Objective: To explore the effects of nutritional support and intervention on intestinal flora, Th cellular immune response and inflammatory response in patients with severe ulcerative colitis. Methods: A total of 90 UC patients who were diagnosed and treated in the hospital between August 2014 and January 2017 were divided into the control group (n=45) and the nutritional intervention group (n=45) by random number table. Control group received clinical routine therapy for UC, and nutritional intervention group received routine therapy as well as nutritional support and intervention. The differences in the intestinal flora distribution, Th1/Th2 cytokine contents and inflammatory mediator contents were compared between the two groups. Results: Before intervention, there was no statistically significant difference in the intestinal flora distribution, Th1/Th2 cytokine contents and inflammatory mediator contents between the two groups. After intervention, the number of enterobacter and enterococcus in nutritional intervention group were lower than those in control group whereas the number of lactobacilli, Bifidobacterium and clostridium butyricum were higher than those in control group; serum IL-2 and IFN-γ contents were lower than those of control group whereas IL-4 and IL-10 contents were higher than those of control group; serum MCP-1, MIP-1a and HMGB-1 contents were lower than those of control group. Conclusion: Nutritional support and intervention can further balance the intestinal flora distribution and Th1/Th2 immune response and suppress the systemic inflammatory response in patients with severe ulcerative colitis.