Objective To detect the change of serum brain-derived neurotrophic factor (BDNF), cortisol and lipid levels in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods 45 patients and 30 healthy controls were involved in this study, and their serum levels of BDNF, cortisol and lipid were tested and compared. The relationship between apnea-hypopnea index (AHI) and several serum markers was analyzed. Results There was a statistical difference in blood pressure, AHI and the lowest oxygen saturation (LSaO2) between the two groups (P < 0. 05). Compared with the control group, the serum level of BDNF was lower in the OSAHS group, while the total cortisol (TC), cholesterol and low-density lipoprotein cholesterol (LDL-C) were higher in the OSAHS group. The serum levels of BDNP and LDL-C among the three mild, moderate and severe OSAHS groups were signifi-cant different. The level of AHI was negatively correlated with BDNP (r = 0. 04, P = 0. 04) in OSAHS patients while positively correlated with LDL-C (r = 0. 12, P = 0. 041). Conclusion The serum levels of BDNP, cortisol and blood lipids change differently in OSAHS patients, and BDNF and LDL-C can be used as indicators of disease severi-ty in OSAHS patients.%目的：检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清脑源性神经生长因子(BD-NF)、皮质醇和血脂水平的变化。方法设置 OSAHS 组(n =45)和健康对照组(n =30),测定并比较血清 BD-NF、皮质醇和血脂水平在两组间的差异；分析 OSAHS 患者中部分血清指标与呼吸暂停低通气指数(AHI)的相关性。结果 OSAHS 组和健康对照组在血压、AHI、最低血氧饱和度(LSaO2)上有统计学差异(P <0．05)；OSAHS 组血清 BDNP 水平较对照组低(P =0．0008),而皮质醇、TC、LDL-C 水平要高(P <0．05)；血清 BDNP、LDL-C 在 OSAHS 轻度组、中度组和重度组间也具有统计学差异(P <0．05)；OSAHS 患者中血清 BDNP 与 AHI呈负相关(r =-0．04,P =0．015),与 LDL-C 呈正相关(r =0．12,P =0．041)。结论 OSAHS 患者血清 BDNP、皮质醇和部分血脂指标的水平发生改变,BDNP 和 LDL-C 或可作为 OSAHS 严重程度的参考指标。
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