Objective To compare the curative effect and complications of minimally invasive transforaminal lumbar interbody fusion and traditional posterior lumbar fusion in treatment of patients with lumbar degenerative disease. Methods The clinical data of 158 patients with lum-bar degenerative disease,including 83 cases by using traditional posterior lumbar interbody fusion as control group,and remaining 75 cases by u-sing minimally invasive transforaminal lumbar interbody fusion in observation group were retrospectively analyzed. The situations of therapeutic effect and complications in patients of these two groups had been compared. Results The amount of intraoperative blood loss and postoperative drainage in patients of observation group were better than those of patients in control group( P 0. 05). Conclusion The rates of efficay of minimally invasive transforaminal lumbar interbody fusion and tradi-tional posterior lumbar interbody fusion in treatment of patients with lumbar degenerative disease are similar,but the former has higher safety with less invasive,less blood loss,less drainage and less complications.%目的：比较微创经椎间孔腰椎椎体间融合术与传统后路腰椎椎体间融合术治疗腰椎退变性疾病的临床效果和并发症情况。方法回顾性分析158例腰椎退变性疾病患者的临床资料，其中83例行传统后路腰椎椎体间融合术设为对照组，余75例行微创经椎间孔腰椎椎体间融合术设为观察组；比较两组患者的治疗效果和并发症情况。结果观察组的术中出血量、术后引流量少于对照组（ P 0.05）。结论微创经椎间孔腰椎椎体间融合术与传统后路腰椎椎体间融合术治疗腰椎退变性疾病的疗效类似，但前者手术损伤更小，出血量与引流量更少，神经损伤发生率更低，具有较高安全性。
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