湖南汉族人群中Toll样受体2和4基因遗传多态性与冠心病的关系

摘要

Objective:To explore Toll-like receptor 2 (TLR2) and TLR4 polymorphism in Han people from Hunan region and its association with coronary atherosclerotic heart disease.Methods:Sanger sequence and statistical analysis were performed to identify the polymorphism of TLR2 and TLR4 genes in 347 unrelated Hunan Han subjects,including 180 healthy people (control group) and 167 patients with coronary atherosclerotic heart disease (coronary atherosclerotic heart disease group).Results:There was no significant difference in the genotype frequency and allelic frequency for TLR2 SNP2258G＞A and TLR4 SNP896A＞G between the 2 groups (P＞0.05),while there was significant difference in the TLR4 SNP1196C＞T between the 2 groups (P＜0.05).Conclusion:TLR4 SNP 1196C ＞T polymorphism is associated with coronary atherosclerotic heart disease in Chinese Han populationin in Hunan region.%目的:探讨湖南地区汉族人群Toll样受体(Toll-like receptor 2,TLR2)及TLR4基因多态性与冠状动脉粥样硬化性心脏病(冠心病)的关系.方法:运用Sanger测序技术检测180例正常对照组及167例无血缘关系湖南汉族人群冠心病组中TLR2 SNP 2258A＞G及TLR4 SNP896A＞G和SNP1196C＞T的多态性.结果:TLR2 SNP 2258A＞G及TLR4SNP896A＞G基因型频率和等位基因频率在冠心病组和正常对照组之间的分布差异无统计学意义(P＞0.05),TLR4SNP1196C＞T在两者之问差异有统计学意义(P＜0.05).结论:湖南地区汉族人群TLR4基因多态性位点SNP1196C＞T与冠心病有关.