精神分裂症患者脑递质功能与临床症状群的关联研究

摘要

目的 用脑涨落图仪探讨精神分裂症患者脑递质功能与其临床症状群之间的关联性.方法 对符合《国际疾病分类(第10版)》精神分裂症诊断标准的80例患者给予脑功能检查,同时用阳性及阴性量表(PANSS)评定患者精神症状.结果 脑内递质相对功率与年龄及文化不相关(P＞0.05);去甲肾上腺素(NE)及兴奋递质3相对功率与PANSS总分呈正相关(r=0.274,P=0.023;r=0.244,P=0.043);思维障碍症状群与NE、兴奋递质3相对功率呈正相关(r=0.281,P =0.019;r=0.249,P=0.039);偏执症状群与乙酰胆碱(Ach)、兴奋递质3相对功率呈正相关(r=0.239,P=0.048;r=0.313,P=0.009);抑郁症状群与5-羟色胺(5-HT)相对功率呈正相关(r=0.266,P=0.027);攻击性症状群与r-氨基丁酸(GABA)、谷氨酸(Glu)相对功率呈负相关,与Ach、NE、多巴胺(DA)及兴奋递质相对功率呈正相关(r=-0.264,P=0.029;r=-0.259,P=0.033;r=-0.242,P=0.047;r=-0.333,P=0.006;r=-0.294,P=0.015;r=-0.315,P=0.009).结论 脑内多种递质相对功率与精神分裂症临床症状群相关.%Objective To explore the correlation between brian neurotransmitter function and clinical symptoms in patients with schizophrenia with encephalofluctuograph instrument.Methods The brain function of 80 patients meeting the International Classification of Diseases 10th edition (ICD-10)diognostic criteria for schizophrenia was tested.The patients' psychiatric symptoms were evaluated with positive and negative rating scale (PANSS).Results The brain relative power of neurotransmitter didn't correlated with age and culture(P ＞0.05).The relative powers of norepinephrine and neurotransmitter of excitement 3 positively correlated with PANSS (r =0.274,P =0.023;r =0.244,P =0.043).Thought disorder symptom clusters positively correlated with the relative powers of norepinephrine and neurotransmitter of excitement 3 (r =0.281,P =0.019;r =0.249,P =0.039).Paranoid symptom clusters positively correlated with the relative powers of acetylcholine and excitatory neurotransmitter 3 (r =0.239,P=0.048;r =0.313,P=0.009).Depressive symptom clusters positively correlated with the relative power of 5-serotonin(r =0.266,P=0.027).Aggressive symptom clusters negatively correlated with the relative powers of r-aminobutyic acid and glutamic acid and positively correlated with the relative powers of acetylcholine,norepinephrine,dopamine,and neurotransmitter of excitement 3(r =-0.264,P =0.029;r =-0.259,P =0.033;r =-0.242,P=0.047;r =-0.333,P=0.006;r =-0.294,P=0.015;r =-0.315,P=0.009).Conclusion The brain relative powers of many neurotransmitters correlates with the clinical symptom clusters of schizophrenia.