目的 探讨食物过敏原特异性IgE、IgG与慢性荨麻疹的关系,为食物过敏的防治提供依据.方法 采用免疫印迹法和ELISA法检测134例慢性荨麻疹患者9种特异性IgE、14种特异性IgG,同时设立健康对照组.结果 过敏原阳性率在不同性别患者间无差别.特异性IgE总阳性率73.1%,以虾、蟹(35.1%)、牛奶(32.1%)、腰果(23.1%)为主,其中,虾、蟹、腰果随年龄增长,阳性率增加,牛奶则降低.特异性IgG总阳性率82.1%,以鸡蛋(40.3%)、牛奶(38.1%)、蟹(38.1%)为主,其中虾、蟹、牛肉随年龄增长,阳性率增加,牛奶、鸡蛋则降低.虾、蟹、牛奶、牛肉的特异性IgE、IgG检测结果 符合性相当好.结论 特异性过敏原的检测是防治食物过敏的重要手段.%Objective To explore the relationship of food allergens specific IgE with IgG and chronic urticaria,and to provide evidence for the prevention and treatment of food allergy. Methods 9 kinds of specific IgE and 14 kinds of specific IgG were detected in serum of 134 cases with chronic urticaria and 30 cases of healthy controls by Western blot and ELISA. Results The positive rates of food allergens had no difference between male and female. The overall positive rates of specific IgE was 73. 1% , among which the top three were shrimps and crabs(35. 1%) ,milk(32. 1%) and cashew(23. 1%) and the positive rates of shrimps, crabs and cashew increased with age,but that of milk decreased. The overall positive rates of specific IgG was 82. 1% ,among with the top three were eggs(40. 3%) ,milk(38. 1%) and crabs(38. 1%) ,and the positive rates of shrimp,crab and beef increased with age,but those of milk and eggs decreased. There were fine coincidence between shrimps and crabs,milk and beef specific IgE and IgG. Conclusion Detection of specific allergens could be an important means of prevention and treatment of food allergy.
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