慢性荨麻疹患者过敏原特异性IgE与特异性IgG分析

摘要

Objective To investigate the diagnosis and significance of serum specific IgE and specific IgG detection in chronic urti-caria allergen.Methods A hospital dermatology treatment of 89 patients with chronic urticaria was as the research object,the ELISA method was used in serum food allergen-specific IgG,while Western blot was used in the detection of serum food allergens and inhalant allergens orig-inal specific IgE.Results Food allergen specific IgG positive rate was 83.15%,and the main food allergens were eggs and milk;food aller-gen-specific IgE-positive rate was 68.54%,and the main food allergens were freshwater fish,marine fish and shrimp crab;inhalant allergen-specific IgE-positive rate was 80.90%,and the main allergens were house dust,mites combinations.Conclusion The combined detection of serum-specific IgE and allergen-specific IgG can give insight into the different aspects of the allergen type and state of the patient's allergies, medical diagnosis and guide treatment of chronic urticaria.%目的：探讨血清特异性IgE和特异性IgG检测在慢性荨麻疹过敏原诊断中的应用价值。方法选取我院皮肤科诊治的慢性荨麻疹患者89例作为研究对象，采用酶联免疫方法检测血清中食物过敏原的特异性IgG，同时采用免疫印迹方法检测血清中食物过敏原和吸入性过敏原的特异性IgE，并进行统计分析。结果食物过敏原特异性IgG的总阳性率为83．15％，主要食物过敏原是鸡蛋和牛奶；食物过敏原特异性IgE的总阳性率为68．54％，主要食物过敏原是淡水鱼、海鱼和虾蟹；吸入性过敏原特异性IgE的总阳性率为80．90％，主要过敏原是屋尘、螨虫组合。结论联合检测患者血清中的过敏原特异性IgE与特异性IgG，能从不同的方面了解患者的变应原种类及患者的过敏状态，指导慢性荨麻疹的诊断与治疗。