目的:探讨玻璃体腔内注射雷珠单抗联合激光治疗糖尿病性黄斑水肿(diabetic macular edema,DME)的临床疗效.方法:回顾性分析2014-06/2016-06于我院眼科治疗的60例60眼DME患者,按照治疗方式不同分为两组,对照组患者采用激光治疗,观察组患者在此基础上联合玻璃体腔内注射雷珠单抗治疗.比较两组患者治疗前和治疗1wk,1、3、6mo后的最佳矫正视力;采用非接触式眼压计测量治疗前后眼压;采用光学相干断层扫描(optical coherence tomography,OCT)测量治疗前后黄斑中心凹厚度(central macular thickness,CMT);记录两组患者术后并发症发生情况.结果:两组患者治疗后视力均显著提高;组间比较:观察组治疗1、3mo后视力均显著高于对照组,差异有统计学意义(P0.05).两组患者治疗后1wk眼压有升高现象,差异有统计学意义(P0.05).两组患者治疗后CMT均显著降低;观察组治疗1、3mo后CMT显著低于对照组,差异有统计学意义(P0.05).观察组6mo内复发5例5眼,复发率17%,对照组复发10例10眼,复发率33%,差异有统计学意义(P0.05). After 1wk of treatment, the two groups'intraocular pressure increased,with statistical significance (P0.05). The postoperative CMT of two groups significantly decreased, data of the observation group at 1, 3mo after treatment was evidently lower than that of the control group, there was statistical significance (P0.05). In the observation group, 5 cases (5 eyes) recurred within 6mo,the recurrence rate was 17%. In the control group, 10 cases (10 eyes) relapsed,the recurrence rate was 33%,the difference was statistically significant (P<0.05). At postoperatively 2d, 2 cases(2 eyes) of the observation group and 3 cases (3 eyes) of the control group had high intraocular pressure, and then returned to normal by given the carteolol eye drops. ·CONCLUSION: Compared with laser therapy alone, intravitreal injection of ranibizumab combined with laser therapy has a significant and safe short-term treatment effective for DME patients with a fast visual acuity recovery.
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