目的:探讨荆花胃康胶丸联合摩罗丹治疗老年慢性萎缩性胃炎伴Hp感染临床疗效及对胃镜组织学影响的研究.方法:选取2014年2月至2016年2月在本院消化科门诊及病房以慢性萎缩性胃炎伴Hp感染的老年患者80例,随机分为两组:对照组40例,予临床常规治疗;实验组40例,在与对照组相同治疗基础上,联合应用荆花胃康胶丸和摩罗丹治疗.观察两组患者治疗前后Hp根除率,胃粘膜萎缩、肠化生、上皮内瘤变等病理组织学积分,其结果应用统计学软件SPSS19.0进行数据分析.结果:与治疗前比较,治疗后两组患者的胃粘膜萎缩、肠化生、上皮内瘤变等病理组织学积分水平降低;与对照组比较,实验组患者治疗后Hp根除率高于对照组,胃粘膜萎缩、肠化生、上皮内瘤变等病理组织学积分低于对照组,以上结果差异均有统计学意义(P<0.05).结论:荆花胃康胶丸联合摩罗丹能有效治疗Hp感染,抑制胃粘膜萎缩、肠化生、上皮内瘤变等病理组织学变化,且具有较好的临床疗效,值得临床推广应用.%Objective:To investigate the effect of the clinical efficacy and gastroscopic histology by Jinghuaweikang capsules combined with Mo Luo Dan in the treatment of senile Gastritis with Hp infection.Method:80 senile chronic atrophic gastritis with Hp positive patients from February 2014 to February 2016 in our hospital were selected and randomly divided into two groups.The control group of 40 cases, treated with routine clinical treatment;40 cases in the experimental group were treated on the basis of the control group with Jinghuaweikang capsules combined with Mo Luo Dan.Observe two groups of patients before and after treatment of Hp eradication rate, gastric mucosal atrophy, intestinal metaplasia, dysplasia and other pathological score, the results using SPSS 19 statistical software for data analysis.Result:Compared with before treatment,two groups of patients Gastric mucosal atrophy, intestinal metaplasia and intraepithelial neoplasia levels were higher after treatment.Compared with the control group, the experimental group patients eradication rate of Hp was higher than that of control group, such as gastric mucosal atrophy, intestinal metaplasia and intraepithelial neoplasia lower than the control group, the differences were statistically significant (P < 0.05).Conclusion:Jinghuaweikang capsules combined with Luo Dan friction can be effective in the treatment of Hp infection, inhibition of gastric mucosal atrophy, intestinal metaplasia, intraepithelial neoplasia and other pathological changes, and has better clinical efficacy, worthy of clinical application.
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