人参、党参、太子参对SD雌性大鼠性成熟的影响

摘要

目的 观察人参、党参、太子参对SD雌性大鼠生长发育的影响. 方法 将动物随机分为对照组、人参组、党参组及太子参组,分别予生理盐水、人参、党参和太子参灌胃2周,并每天行阴道涂片检查,干预前后检测雌二醇(Estrogen,E2)水平,最后解剖大鼠,取出卵巢和子宫,计算卵巢指数和子宫指数.结果 四组大鼠比较,性成熟时间和卵巢指数未见明显差异;与对照组相比,党参组、人参组的E2水平明显升高(P<0.05);与对照组和太子参组相比,人参组的子宫指数较大(P<0.05);与对照组相比,三个给药组大鼠体重增长较多(P<0.05).结论 党参和人参在一定程度上可能导致SD雌性大鼠的性早熟;人参、党参、太子参能促进SD雌性大鼠体重的增长.%Objective To observe the effects of ginseng, radix codonopsis and radix pseudostellariae on the growth and development of SD female rats.Methods Animals were randomly divided into four groups: control group, ginseng group, radix codonopsis group and radix pseudostellariae group, intragastric administration for 2 weeks with normal saline, ginseng, radix codonopsis and radix pseudostellariae, vaginal smears were taken every day.The levels of estrogen before and after intervention were detected.The ovarian index and uterine index was calculated.Results There was no significant difference in sexual maturation time and ovarian index of the four groups.Compared with the control group, the E2 level of radix codonopsis group and ginseng group was significantly increased(P<0.05).Compared with the control group and the radix pseudostellariae group, the uterus index of the ginseng group was larger(P<0.05).Compared with the control group, the rats in the rest groups had more weight gain (P<0.05).Conclusion Ginseng and radix codonopsis may lead to precocious puberty of SD female rats in a certain degree;Ginseng,radix codonopsis and radix pseudostellariae can promote the weight growth of SD female rats.