北方地区成人脂肪肝危险因素的病例对照研究

摘要

[Objective] To investigate the risk factors for fatty liver disease in northern people. [Method] Data of case-control study including 294 cases and 655 controls were analyzed using non-conditional logistic regression. [Result] Overweight ( OR = 6. 3, 95% CI = 4.4, 8.9), obesity (OR = 16.9, 95% CI = 9. 9, 28. 9), abdominal obesity (OR = 2.9, 95% CI = 1. 9, 4. 5 ) , dyslipidemia (OR = 2. 1, 95% CI = 1.5, 3.0) and ST-T changes (OR = 1.6, 95% CI = 1. 0, 2. 3) were significantly associated with the risk of fatty liver disease (P < 0.05). High intake of meat, high-salt diet and pressure were the risk factors of fatty liver disease, and the OR values were 1.5 (95% CI, 1.0,2.1), 1.5 (95% CI, 1.1,2.1) and 1.4(95% CI, 1.0,2.2), respectively. Eating at home more than 5 d was a protective factor for fatty liver and the OR value was 0.6 (95% CI 0.4, 0. 9) . [Conclusion] The occurrence of fatty liver is closely associated with metabolic diseases and unhealthy lifestyle.%目的:探索北方地区成人脂肪肝的危险因素.方法:采用病例对照研究对294名病例和655名对照的相关资料进行非条件Logistic回归分析.结果:超重(OR =6.3,95％ CI =4.4,8.9)、肥胖(OR=16.9,95％ CI=9.9,28.9)、腹型肥胖(OR=2.9,95％ CI=1.9,4.5)、血脂异常(OR =2.1,95％ CI=1.5,3.0)及ST-T改变(OR=1.6,95％ CI=1.0,2.3)与脂肪肝的患病明显相关(P＜0.05).摄入肉类较多、高盐饮食及自觉压力较大均为脂肪肝的危险因素,其OR值分别为1.5 (95％ CI,1.0,2.1)、1.5 (95％ CI,1.1,2.1)及1.4 (95％ CI,1.0,2.2).在家就餐超过5d为脂肪肝的保护因素,OR为0.6(95％ CI,0.4,0.9).结论:脂肪肝的发生与代谢性疾病及生活方式密切相关.