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>Associations between Dietary Total Antioxidant Capacity and Risk of Nonalcoholic Fatty Liver Disease (NAFLD) in Adults: A Case-Control Study
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Associations between Dietary Total Antioxidant Capacity and Risk of Nonalcoholic Fatty Liver Disease (NAFLD) in Adults: A Case-Control Study
Background and Objectives: Dietary total antioxidant capacity (DTAC) is suggested as a useful tool for the assessment of relationships between cumulative antioxidant food capacities and several chronic disorders. However, relationships between the total antioxidant capacity of the diet (TAC) and the risk of NAFLD has not previously been assessed. The aim of this study was to assess relationships between DTAC and risk of NAFLD in a case-control study. Materials and Methods: This case-control study was carried out on 158 patients with NAFLD and 357 healthy individuals aged 18–55 years. Dietary data were collected using validated 168- items quantitative food frequency questionnaires. Triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDLC) and fasting blood glucose (FBS) concentrations were assessed using enzymatic methods and commercial kits. The DTAC was calculated based on the oxygen radical absorbance capacity of each food (except for coffee) reported by US Department of Agriculture. Statistical Analysis was carried out using SPSS Software. Results: The mean±SD (standard deviation) for age and body mass index (BMI) of the study participants were 43.9 years ±5.9 and had 30.5 kg/m2 ±2.6. The NAFLD patients included higher BMI and female proportion, compared to control group. The NAFLD patients included higher smoking rates, biochemical parameters (TG, TC, HDL-C, LDL-C and FBS) and DTAC scores, compared to control groups. However, patients with NAFLD included lower HDL levels and physical activities, compared to control group. The highest tertile of DTAC showed lower risks of NAFLD, compared to the lowest tertile. This association was significant after controlling for potential confounders (p for trend 0.001). Conclusions: Findings suggest that promotion of naturally increased antioxidant capacities may help prevent development of NAFLD.
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机译：背景和目标：建议膳食总抗氧化能力（DTAC）作为评估累积抗氧化食品能力和几种慢性疾病之间的关系的有用工具。然而，先前尚未评估饮食总抗氧化能力与NAFLD的风险之间的关系。本研究的目的是评估案例对照研究中DTAC与NAFLD风险之间的关系。材料与方法：在18-55岁患者的158例NAFLD和357名健康个体患者中进行了这种情况对照研究。使用验证的168项定量食品频率问卷收集膳食数据。使用酶法和商业试剂盒评估甘油三酯（TC），总胆固醇（TC），高密度脂蛋白（HDL-C），低密度脂蛋白（LDLC）和空腹血糖（FBS）浓度。 DTAC基于美国农业部报告的每种食物（咖啡除外）的氧自由基吸收能力计算。使用SPSS软件进行统计分析。结果：研究参与者年龄和体重指数（BMI）的平均值±SD（标准偏差）为43.9岁±5.9，具有30.5 kg / m2±2.6。与对照组相比，NAFLD患者包括更高的BMI和女性比例。与对照组相比，NAFLD患者包括更高的吸烟率，生物化学参数（TG，TC，HDL-C，LDL-C和FBS）和DTAC分数。然而，与对照组相比，NAFLD患者包括较低的HDL水平和体育活动。与最低的Tertive相比，DTAC的最高型号显示出较低的NAFLD风险。在控制潜在的混乱后，这种关联是显着的（p用于趋势<0.001）。结论：研究结果表明，促进自然增加的抗氧化能力可能有助于预防NAFLD的发展。
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