钙信号在糖尿病周围神经病变中感觉神经元和神经胶质细胞功能异常的研究进展

摘要

在周围神经系统中,钙信号是信息处理的基础,几乎所有的生理活动都受到Ca2+的调控.Ca2+可调节细胞功能,钙信号和钙稳态直接与神经病变有关.近年来,钙信号功能的报道,为研究糖尿病周围神经病变发病机制及其治疗方向提供了新的思路.该文从钙信号与糖尿病周围神经病变中感觉神经元和神经胶质细胞的关系等方面进行综述.%Ca2+signaling is fundamental for information process-ing in the peripheral nervous system,which regulates a variety of physiological activities.Ca2+signaling and calcium homeostasis are directly associated with neuropathology.Recently,studies on Ca2+signaling contribute to a deeper comprehension of the path-ogenesis of diabetic peripheral neuropathies,which provide a new research direction for the treatment of diabetic peripheralneuropathies.This review aims to highlight the relationship be-tween calcium signaling,sensory neurones and neuroglial cells in the context of diabetic peripheral neuropathies.