组织工程技术在感染性骨缺损治疗中的应用及优势

摘要

背景:感染性骨缺损的治疗方法很多,但没有一种同时兼备缓释抗炎、成骨活性、骨传导作用、可降解吸收的一期治疗方法.目的:探讨骨组织工程技术治疗感染性骨缺损的研究进展.方法:应用计算机检索PubMed数据库、万方数据库及CNKI中国知网数据库2000至2016年相关文献,包括:①抗生素局部应用相关基础、临床研究;②抗生素缓释系统治疗感染性骨缺损的基础研究;③种子细胞的来源及成骨机制相关基础研究;④支架材料研发相关文章.共纳入55篇文献进行分析.结果与结论:①局部应用抗生素的方法在治疗骨髓炎中均有着不同的效果;②骨组织工程学的发展为骨缺损治疗带来新的希望,选择优良的种子细胞也因此成为了研究的热点和难点;③抗生素、种子细胞和可吸收支架材料的完美结合为感染性骨缺损的一期治疗提供可能.%BACKGROUND:There are many treatment methods for infected bone defects,but there is no first stage treatment method,which has the characteristics of sustained-release,anti-inflammation,osteogenic activity,bone conduction and degradable absorption.OBJECTIVE:To investigate the research progress of bone tissue engineering technique in the treatment of infected bone defects.METHODS:A computer-based retrieval of PubMed,WanFang and CNKI databases was conducted for the articles published from 2000 to 2016,concerning the basic and clinical research on the local application of antibiotics;basic research on infected bone defects with sustained-release of antibiotics;basic studies on the source of seed cells and the osteogenic mechanism;and scaffold materials.A total of 55 eligible articles were included for result analysis.RESULTS AND CONCLUSION:Topical application of antibiotics exhibits different effects in the treatment of osteomyelitis.The development of bone tissue engineering has brought new hope for the treatment of bone defects,and in the meanwhile,selection of excellent seed cells has become a hot and difficult research.A rational combination of antibiotics,seed cells and scaffold materials may provide a new treatment strategy for infected bone defects.