Objective To understand the adverse reaction profile of linezolid during clinical treatment,especially lactic acidosis and pancytopenia.Methods One case of linezolid-induced lactic acidosis and pancytopenia was described in a patient receiving long-term treatment in our hospital.Similar cases were searched and identified from literatures reports both in China and abroad from 2000 to 2015 for further review.The data were analyzed in terms of patient age,sex,underlying conditions,as well as onset time,clinical characteristics,and outcomes of the adverse reaction.Results A total of 50 similar cases (male/female ratio:1.78∶1) were analyzed,42.0％ of which were old patients (at least 65 years old).Liver and/or renal insufficiency was found in 20 cases (40.0％).The onset of lactic acidosis was at 5.5 weeks after initiation of linezolid on average,and the onset of pancytopenia was at 3.5 weeks after initiation of linezolid.Conclusions Linezolid-induced lactic acidosis or pancytopenia is more frequently found in the elderly patients with hepatic dysfunction and long-term treatment.%目的 了解利奈唑胺在临床应用过程中不良反应发生情况,尤其是导致乳酸酸中毒或全血细胞减少的发病特点.方法 报告1例长疗程应用利奈唑胺致乳酸酸中毒及全血细胞减少的病例,并对2000-2015年国内外报道的相关文献进行复习,对患者的年龄、性别、基础疾病、不良反应出现时间、预后等情况进行总结分析.结果 50例统计分析结果:患者男女比例为1.78∶1,65岁以上患者占42.0％,肝、肾功能不全者20例(占40.0％),乳酸酸中毒平均出现于用药后5.5周,全血细胞减少平均出现于用药后3.5周.结论 利奈唑胺致乳酸酸中毒或全血细胞减少更多出现于肝功能受损、长疗程用药和高龄的患者.
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