利奈唑胺致慢性肾脏病患者转氨酶升高、血小板减少、乳酸酸中毒一例并文献复习

摘要

A patient with end-stage renal disease,had the symptom of elevated transaminases,thrombocytopenia and lactic acidosis after linezolid therapy. The author analyzed the case, and suggested that both symptoms and laboratory tests should be monitored after linezolid was given. Further studies were needed to elucidate the safety and tolera-bility of linezolid in chronic kidney disease patients.%1例终末期肾脏病患者,使用利奈唑胺后出现转氨酶升高、血小板减少和乳酸酸中毒并发症,停药后病情得到缓解.本文通过对该病例资料进行分析,提示慢性肾脏病患者使用利奈唑胺时,需要密切监测患者临床症状及相关实验室检查.利奈唑胺在该人群中应用的安全性和耐受性需要临床进一步验证.