白藜芦醇对急性失血性休克患者部分血清白介素的影响及继发性心、肺损伤的保护作用研究

摘要

目的：探讨白藜芦醇对急性失血性休克患者部分血清白介素的影响及继发性心、肺损伤的保护作用。方法收集河北省邢台市人民医院救治的急性失血性休克患者42例，根据用药不同分为对照组和实验组，每组各21例。对照组患者均给予持续低流量吸氧、补液等基础治疗，必要时给予输血；实验组在对照组基础上给予白藜芦醇30 mg／kg，口服，1次／天，连续4周。治疗期间检测患者各项生命指标，治疗结束后对所有患者的血清血清CK、LDH、IL－6、IL－10、IL－12、LVP、＋dp ／dtmax、－dp ／dtmax水平以及动脉血气进行检测。结果治疗后，与对照组相比，实验组患者的CK、LDH 水平显著下降（ P＜0．05）；IL－6、IL－10、IL－12水平明显下降（P＜0．05）；LVP、＋dp ／dtmax、－dp ／dtmax水平明显上升（P＜0．05）； PaCO2、pH水平明显下降，PaO2水平明显上升（P＜0．05）。结论白藜芦醇能够显著降低失血性休克患者血清白介素IL－6、IL－10、IL－12各指标水平、降低CK、LDH 水平，从而缓解患者心、肺损伤。%Objective To investigate the effect of resveratrol on levels of serum interleukin family of acute hemorrhagic shock patients and study its protective effect for secondary heart and lungs injury.Methods 42 cases of acute hemorrhagic shock were collected and divided into experimental group and control group according to different drugs treatment, each group had 21 cases.Control group were given continuous low flow oxygen, fluid infusion and other basic treatment, given blood transfusion if necessary.On the basis of control group, experimental group was given resveratrol 30 mg/kg, orally, one time per day for 4 consecutive weeks.The life index were detected during the treatment period.Then the levels of serum CK, LDH, IL-6, IL-10, IL-12, LVP, +dp/dtmax ,-dp /dtmax and arterial blood gas of all patients were detected after treatment.ResuIts Compared with control group, the levels of CK and LDH in experimental group decreased significantly (P<0.05);IL-6, IL-10, IL-12 levels decreased significantly (P<0.05).LVP,+dp /dtmax , -dp /dtmax level increased significantly ( P<0.05 ); PaCO2 and pH levels decreased significantly, the level of PaO2 increased significantly (P<0.05).ConcIusion Resveratrol can significantly reduce the serum IL-6, IL-10, IL-12l, reduce the CK, LDH level of hemorrhagic shock patients, and alleviate the injury of heart and lung.