舒肝解郁胶囊联合舍曲林治疗产后抑郁症患者的临床效果

摘要

目的 探讨舒肝解郁胶囊与舍曲林联合治疗产后抑郁症(PPD)患者的临床效果及对其生活质量的影响.方法 回顾性选取2014年7月~2015年11月浙江省湖州市第三人民医院收治的产后抑郁症患者的72例,随机平均分为2组,每组36例,对照组患者选用常规治疗药物舍曲林,研究组在对照组用药基础上联合舒肝解郁胶囊共同治疗.均治疗6w.分析比较2组患者入院时、治疗后4和6 w后的汉米尔顿抑郁量表(HAMD)评分、副反应量表(TESS)和生活质量指数量表评分(QL-Index)变化.结果 治疗后,研究组HAMD、TESS分别为(0.92±0.58)和(1.36±0.46),显著低于对照组(1.67±0.43)和(2.48±0.72),差异具有统计学意义(P<0.05);研究组QL-Index评分为(7.83±1.68),显著高于对照组(6.79±1.24),差异具有统计学意义(P<0.05).结论 舒肝解郁胶囊与舍曲林联合治疗产后抑郁症患者效果显著,能显著改善患者抑郁状态,提高患者的生活质量,且不良反应小.%Objective To investigate the clinical effects of Shugan Jieyu Capsule combined with sertraline in the treatment of postpartum depression (PPD), to improve the postpartum depression and quality of life.Methods 72 cases of postpartum depression treated in our hospital were retrospectively chosen.They were randomly divided into two groups, each group was of 36 patients, and they were taken with different drug regimen.The control group was treated with conventional treatment drug sertraline, and the study group was taken with Shugan Jieyu capsule on the basis of the control group.six weeks of treatment were as the observation period, and the differences of scores of HAMD, TESS and Quality of Life Index for the two groups on admission, four and six weeks after treatment were compared.Results After treatment, the scores of HAMD, TESS and QL-Index of the study group were (0.92 ±0.58), (1.36 ±0.46), (7.83 ±1.68), significantly better than the control group of (1.67 ±0.43), (2.48 ±0.72), (6.79 ±1.24), ( P <0.05 ) .Conclusion The combination of Shugan Jieyu Capsule and sertraline can improve the patients'quality of life after the treatment of postpartum depression, the depression is improved, and with few adverse reactions.It has a positive effect in improving the quality of life of patients.